Responsive Prodrug Self-Assembled Vesicles for Targeted Chemotherapy in Combination with Intracellular Imaging

摘要

Targeted drug delivery systems having controlled drug release property with an inherent fluorescence reporter have drawn a lot of attention-in nanomedicine. However, only very few prodrugs can be directly Used to construct such delivery systems. Herein, we report that an amphiphilic chlorambucil-based prodrug consisting of a fluorescence reporter and a D-mannose targeting ligand could directly self-assemble into glutathione-responsive nanovesicles for selective cancer therapy and intracellular imaging. These nanovesicles could be dissociated to release the chlorambucil drug :with obviously red-shifted fluorescence when internalized by D-mannose receptor-overexpressed MCF-7 cancer cells. in addition, the nanovesicles displayed better selectivity and higher therapy efficiency than free chlorambucil drug.