Dynamic multivalency for carbohydrate-protein recognition through dynamic combinatorial libraries based on Fe~(II)-bipyridine complexes

摘要

Molecular recognition: Dynamic combinatorial libraries (DCLs) exploiting multivalency effects and metal coordination have been employed for carbohydrate-protein recognition. The interaction of a three-component DCL based on 2,2′-bipyridine (bipy)-Fe~(II) complexes with concanavalin A (ConA; see scheme) results in enhanced binding by multivalent presentation with a bias towards mannose-containing library components.