Cobalt-catalyzed direct arylation of unactivated arenes with aryl halides

摘要

Inexpensive and simple: The direct arylation of unactivated arenes with aryl halides has been carried out with [Co(acac)3] as the catalyst and LiHMDS as the base. The corresponding biaryl compounds have been prepared in good to excellent yields and at a relatively low reaction temperature (see scheme; acac=acetylacetonate, LiHMDS=lithium bis(trimethylsilyl)amide). An intramolecular direct arylation has also been achieved under the same conditions.