Identification of novel alpha7 nAChR positive allosteric modulators with the use of pharmacophore in silico screening methods.

摘要

The pharmacophore model of in house potent and selective alpha7 nAChR positive allosteric modulators is reported. The model was used to fish out commercially-available compounds from corporate 3D databases. As a result, novel alpha7 positive modulator chemotypes were identified. A rat full PK profile of a representative compound is also described.