Structural Diversity and Bioactivity of Labdane and Clerodane Diterpenoids

摘要

More than a thousand compounds possessing labdane and clerodane-type skeletons have been isolated from the natural sources,such as plants,marine products,fungi,and bacteria.These diterpenoids form big groups in secondary metabolites.Biogenetically,both the labdane and clerodane skeletons are derived from geranyl geranylpyrophosphate.However,their biological roles are not well known.This review describes current issues in research on labdane and clerodane-type diterpenoids,including the rearranged skeletons,related to their structural diversity and bioactivities.Synthetic challenges relevant to labdane and clerodane-type diterpenoids,an example of an enantiomeric labdane-type diterpene,and a recent genomic study of the biosynthesis of diterpenoids are also described.