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Labdane and Clerodane Diterpenoids from Colophospermum mopane

机译:oph豆中的Labdane和Clerodane二萜

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Five labdane (1-5), an isolabdane (6), and five clerodane diterpenoids (7-11), were isolated from seeds, husks, and leaves of Colophospermum mopane. Compounds 1-3 and 6-9 are new, and their structures were elucidated by means of physical data analysis (1D and 2D NMR, HRESIMS). The absolute configurations of 1, 7, and 10 were determined by single-crystal X-ray diffraction with Cu K alpha radiation. For compounds 2 and 6, the absolute configurations were established by the modified Mosher's method and corroborated by comparison of experimental and calculated electronic circular dichroism spectra of their 3-p-bromobenzoate derivatives. The crude extracts and compounds were evaluated for antimicrobial activity. The leaf extract was the most active against Staphylococcus aureus (125 mu g/mL). Compound 11 showed the best inhibitory activity, with minimum inhibitory values of 15.6 mu g/mL against Escherichia coli and Staphylococcus aureus and 31.3 mu g/mL against Enterococcus faecalis.
机译:从of草的种子,果壳和叶子中分离出五种拉丹烷(1-5),异拉丹烷(6)和五种环戊烷二萜类化合物(7-11)。化合物1-3和6-9是新化合物,通过物理数据分析(1D和2D NMR,HRESIMS)阐明了它们的结构。用Cu Kα射线通过单晶X射线衍射确定1、7和10的绝对构型。对于化合物2和6,通过改进的Mosher方法建立了绝对构型,并通过比较其3-对溴苯甲酸酯衍生物的实验和计算的电子圆二色性光谱,证实了其绝对构型。评价粗提取物和化合物的抗微生物活性。叶提取物对金黄色葡萄球菌的活性最高(125μg / mL)。化合物11显示出最佳的抑制活性,对大肠杆菌和金黄色葡萄球菌的最小抑制值为15.6μg/ mL,对粪肠球菌的最小抑制值为31.3μg/ mL。

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