Structural and functional characteristics of heterodimeric phosphatidilinositol-3-kinases and molecular mechanisms of their conjugation with other signaling system components

摘要

This review presents literary data and results of the author own studies on structural and functional characteristics of regulatory (p55/p85) and catalytic (p110) subunits of heterodimeric phosphatidylinositol-3-kinases (PI-3-kinases), and on molecular mechanisms of their functional conjugation with other signaling system components, regulated by insulin and growth factors. Various models simulating the interaction of regulatory subunits of PI-3-kinase and of their substrates (insulin receptor sustrate proteins phosphorylated on tyrosin residues) with molecules of receptor-tyrosinekinases have been considered. Mechanisms of the functional conjugation between regulatory and catalytic enzyme subunits are discussed, with special reference to a possible role of the coiled-coil interactions in this process.