Differential TLR-induced cytokine production by human mast cells is amplified by Fc epsilon RI triggering

摘要

BackgroundMast cells are mainly present in strategic locations, where they may have a role in defence against parasites and bacteria. These pathogens can be recognized by mast cells via Toll-like receptors (TLR). Allergic symptoms are often increased in the presence of pathogens at the site of allergen exposure, but it is unknown which cytokines can mediate such an effect.