The red cell membrane, Part 2: Disorders of the red cell membrane

摘要

XA Anemia, which is the most common symptom of red cell abnormalities, affects approximately one-quarter of people globally. In a report from the Global Burden of Disease Study 2010, which was published in the Lancet in 2012, anemia was the most important disorder in terms of its overall contribution to global years lived with disability (YLDs). The overall burden of anemia was large—68.2 million YLDs, or almost one-tenth (8.8%) of all YLDs worldwide—reflecting both the high prevalence of anemia and the moderately severe disability it produces, especially in cases of severe anemia. By far the most important contributor to this health loss was iron-deficiency anemia, which accounted for 62.2% of anemia YLDs globally. The second-leading specific cause of anemia YLDs was thalas-semia (6.7% of total anemia YLDs), which was followed by malaria (4.9%). Hookworm and sickle cell anemia together accounted for a further 7.2%.