Nanomolding of Nano-Structured Biodegradable Scaffolds

摘要

In this study, we demonstrate a replica mold fabrication method for nano-hemisphere arrays nanomolding by nickel electroforming using the highly ordered nano-hemisphere array of the barrier-layer surface of an anodic aluminum oxide (AAO) membrane as the master mold. The feature size of the nano-hemispheres can be controlled by the use of different etching solutions for anodic oxidation of aluminum. Using the nickel replica mold, nano-structured tissue engineering scaffolds in poly(lactic-co-glycolic acid) (PLGA), polylactide (PLA), and chitosan were fabricated by casting.