The present invention relates to a composition comprising a mesenchymal stem cell-hydrogel-biodegradable scaffold or a mesenchymal stem cell-hydrogel-non-degradable scaffold, a sheet and a method for producing the same, more specifically, to a mesenchymal stem cell The sheet containing hydrogel-biodegradable or non-degradable scaffold can be applied to the affected part of a patient suffering from bullous epidermolysis without the proteolytic enzyme isolation, and secreted from mesenchymal stem cells The extracellular matrix such as collagen, laminin, fibronectin, and elastin is present in the hydrogel completely, thereby exhibiting a remarkable advantageous effect on skin regeneration and re-epithelialization ability as compared with the conventional dressing agents used in the water-borne epidermal dissipation.
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