Effect of damages of capsaicin-sensitive nerves on alpha1-antitrypsin activity in the rat blood

摘要

Systemic administration of capsaicin (a neurotoxin of afferent nerves) in a dose of 150 mg/kg led to a decrease in the activity of alpha 1-antitrypsin (alpha 1-AT) in the blood of male Wistar rats. This effect is related to impairment of the local effector function of capsaicin-sensitive nerves in the liver, which is the main source of alpha 1-AT in the blood. Analogous results were obtained upon cutting of the hepatic branch of the vagus nerve involving capsaicin-sensitive afferent fibers of the liver.