Empirical search for factors affecting mean particle size of PLGA microspheres containing macromolecular drugs

摘要

Background and objectives: Poly(lactic-co-glycolic acid) (PLGA) has become one of the most promising in design, development, and optimization formedical applications polymers. PLGA-based multiparticulate dosage forms are usually prepared as microspheres where the size is from 5 to 100 mu m, depending on the route of administration. The main objectives of the study were to develop a predictive model of mean volumetric particle size and on its basis extract knowledge of PLGA containing proteins forming behaviour.