首页> 外文期刊>Materials science & engineering >PLGA-based microparticles loaded with bacterial-synthesized prodigiosin for anticancer drug release: Effects of particle size on drug release kinetics and cell viability
【24h】

PLGA-based microparticles loaded with bacterial-synthesized prodigiosin for anticancer drug release: Effects of particle size on drug release kinetics and cell viability

机译:载有细菌合成的prodigiosin的基于PLGA的微粒可用于抗癌药物释放:粒径对药物释放动力学和细胞活力的影响

获取原文
获取原文并翻译 | 示例
           

摘要

This paper presents the synthesis and physicochemical characterization of biodegradable poly (D,L-lactide-co-glycolide) (PLGA)-based microparticles that are loaded with bacterial-synthesized prodigiosin drug obtained from Serratia marcescens subsp. Marcescens bacteria for controlled anticancer drug delivery. The micron-sized particles were loaded with anticancer drugs [prodigiosin (PG) and paclitaxel (PTX) control] using a single-emulsion solvent evaporation technique. The encapsulation was done in the presence of PLGA (as a polymer matrix) and poly-(vinyl alcohol) (PVA) (as an emulsifier). The effects of processing conditions (on the particle size and morphology) are investigated along with the drug release kinetics and drug-loaded microparticle degradation kinetics. The localization and apoptosis induction by prodigiosin in breast cancer cells is also elucidated along with the reduction in cell viability due to prodigiosin release. The implication of this study is for the potential application of prodigiosin PLGA-loaded microparticles for controlled delivery of cancer drug and treatment to prevent the regrowth or locoregional recurrence, following surgical resection of triple negative breast tumor.
机译:本文介绍了可生物降解的聚(D,L-丙交酯-共-乙交酯)(PLGA)为基础的微粒的合成和理化特性,这些微粒载有从粘质沙雷氏菌(Serratia marcescens subsp。)获得的细菌合成的前靛蓝素药物。 Marcescens细菌可控制抗癌药物的传递。使用单乳液溶剂蒸发技术,将微米级的颗粒装载有抗癌药[prodigiosin(PG)和紫杉醇(PTX)对照]。包封是在PLGA(作为聚合物基质)和聚乙烯醇(PVA)(作为乳化剂)存在下进行的。研究了加工条件(对粒径和形态)的影响,以及药物释放动力学和载药微粒降解动力学。还阐明了prodigiosin在乳腺癌细胞中的定位和凋亡诱导,以及由于prodigiosin释放引起的细胞活力降低。这项研究的意义在于,在外科手术切除三阴性乳腺癌后,载有普鲁迪高新素PLGA的微粒可潜在地用于控制癌症药物的输送和治疗,以防止再生长或局部复发。

著录项

  • 来源
    《Materials science & engineering》 |2016年第9期|51-65|共15页
  • 作者单位

    Department of Materials Science and Engineering, African University of Science and Technology (AUST), Abuja, Nigeria ,Department of Mechanical and Aerospace Engineering, Princeton University, USA;

    Department of Materials Science and Engineering, African University of Science and Technology (AUST), Abuja, Nigeria ,Department of Materials Science and Engineering, Kwara State University, Malete, Ilorin, Kwara State, Nigeria;

    Department of Materials Science and Engineering, African University of Science and Technology (AUST), Abuja, Nigeria ,Biotechnology and Genetic Engineering Advanced Laboratory, Sheda Science and Technology Complex (SHESTCO), Abuja, Nigeria;

    Department of Materials Science and Engineering, African University of Science and Technology (AUST), Abuja, Nigeria ,Biotechnology and Genetic Engineering Advanced Laboratory, Sheda Science and Technology Complex (SHESTCO), Abuja, Nigeria;

    Department of Mechanical and Aerospace Engineering, Princeton University, USA ,Princeton Institute of Science and Technology of Materials (PRISM), Princeton, USA ,Department of Chemistry, Bronx Community College, New York NY, USA;

    Department of Mechanical and Aerospace Engineering, Princeton University, USA ,Princeton Institute of Science and Technology of Materials (PRISM), Princeton, USA;

    Department of Biomedical Engineering, Rutgers University, Piscataway, USA;

    Department of Biomedical Engineering, Rutgers University, Piscataway, USA ,Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, USA;

    Department of Materials Science and Engineering, African University of Science and Technology (AUST), Abuja, Nigeria ,Department of Mechanical and Aerospace Engineering, Princeton University, USA ,Princeton Institute of Science and Technology of Materials (PRISM), Princeton, USA;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Microparticles; Prodigiosin; Paclitaxel; Poly (D,L-lactide-co-glycolide); Encapsulation efficiency; Drug release kinetics; Degradation;

    机译:微粒;Prodigiosin;紫杉醇;聚(D;L-丙交酯-乙交酯);封装效率;药物释放动力学;降解;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号