A computer system for simulating population dynamics of patterns of polygenes and mobile genetic elements upon truncation selection for a quantitative trait

摘要

A computer system was developed for simulation of population dynamics of interacting polygene patterns and mobile genetic elements (AGEs) under selection for a quantitative trait. The system is stochastic (Monte Carlo) and takes into account the main sources of random change in the patterns (recombinations, transpositions, excisions), genetic drift, and determined trends of selection and other genetic processes in a finite population. Using this model, it is possible to analyze the dynamics of many population parameters that cannot be experimentally estimated: frequencies of polygenic alleles, proportions of adaptive and random fixations, average heterozygosities of polygenes and AGEs, coefficient of inbreeding, heritability, etc. In addition, the model can be use dot test various hypotheses on polygene-MGE interaction.