首页> 外文期刊>Clinica chimica acta: International journal of clinical chemistry and applied molecular biology >False positive PTH results: an easy strategy to test and detect analytical interferences in routine practice.
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False positive PTH results: an easy strategy to test and detect analytical interferences in routine practice.

机译:假阳性PTH结果:在常规实践中测试和检测分析干扰的简便策略。

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摘要

BACKGROUND: As other immunoassays, PTH determination is not free from interferences. Indeed, natural antibodies like heterophile antibodies (HAMA) and rheumatoid factor (RF) can induce falsely elevated results, leading to misdiagnosis and expensive unnecessary explorations. However, in routine practice, these interferences are not always obvious to detect. METHODS: On 2084 PTH samples, we applied a validation strategy in four steps to screen for HAMA and rheumatoid factor interferences. RESULTS: 36% of our samples presented an elevated PTH. We found a clinically plausible reason for 91% of them. The remaining 63 suspicious samples were treated with HBT and 40% of them were found to be HAMA positive. RF determination was performed on the HAMA-negative samples and RF was positive in 21 of them. They were then treated with RF-Absorbent. Nine of these 21 samples presented RF interference. CONCLUSION: Applying this strategy in our routine validation, we managed to avoid spuriously elevated PTH results, which could have caused medical errors as well as unnecessary cost-effective extra-investigations.
机译:背景:与其他免疫测定法一样,PTH的测定并非没有干扰。实际上,天然抗体(如嗜异性抗体(HAMA)和类风湿因子(RF))会诱导错误地升高结果,从而导致误诊和昂贵的不必要探索。但是,在常规实践中,这些干扰并不总是很容易检测到。方法:在2084个PTH样本上,我们分四步应用了一种验证策略来筛选HAMA和类风湿因子干扰。结果:我们的样本中有36%的PTH升高。我们发现其中91%的临床上合理的原因。其余63个可疑样品接受了HBT处理,其中40%被发现为HAMA阳性。对HAMA阴性样品进行RF测定,其中21个样品RF呈阳性。然后将它们用RF吸收剂处理。这21个样本中有9个呈现出RF干扰。结论:在我们的常规验证中应用了该策略,我们设法避免了假性PTH结果升高,该结果可能会导致医疗错误以及不必要的具有成本效益的额外调查。

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