COMMENT ON “PROTECTIVE ARMS OF THERENIN–ANGIOTENSIN SYSTEM INNEUROLOGICAL DISEASE”: REPLY

摘要

We thank Drs Smith and Muralidharan for their interest in ourreview article,1which was updating recent neurological researchrelated to the angiotensin (Ang) II AT2receptor (AT2R), includ-ing their own recent data. The following reply addresses theircomments.First, as stated twice on p. 582 of our article, we believe thatPD123319 is a standard tool in AT2R research and we neverquestioned that it has AT2R antagonistic properties.1Second, thecorrect citation of our article is as follows:Two very recent publications provide experimental evidencethat EMA401 and analogues indeed reduce neurite density ofhuman dorsal root ganglia and neurite length in AngII-treated ratdorsal root ganglia and that they exert antinociceptive actions.2,3However, neither of these two studies provided conclusive proofthat the compounds tested are AT2R antagonists.