Successful pregnancy following in vitro fertilization embryo transfer in a 46-year-old woman with diminished oocyte reserve as evidenced by a high day 3 serum estradiol.

摘要

PURPOSE: To establish a precedent that a successful pregnancy is possible following in vitro fertilization-embryo transfer (IVF-ET) even in a 46-year-old woman with diminished egg reserve. METHODS: Mild ovarian stimulation was used to stimulate multiple follicles in a woman whose diminished oocyte reserve was manifested by elevated day 3 serum estradiol and top normal serum follicle stimulating hormone (FSH). RESULTS: She conceived on her third IVF-ET attempt. She delivered a healthy full term baby girl. CONCLUSIONS: This is believed to be the first case report of a successful pregnancy in a woman of this advanced age with diminished oocyte reserve using her own oocytes. It establishes a precedent showing others in similar circumstances that a pregnancy is at least possible though unlikely.