A drop in serum estradiol the day after human chorionic gonadotropin (hCG) shot does not adversely affect pregnancy rates per embryo transfer in women with very decreased oocyte reserve

摘要

Some studies with "normal" responders have found lower pregnancy rates if the serum estradiol (E2) decreases the day after human chorionic gonadotropin (hCG) injection. However, this is the norm in natural cycles. The present study evaluated the effect of a drop in serum E2 the day after hCG injection in women with diminished oocyte reserve using mild FSH stimulation. The clinical and live delivered pregnancy rates (PRs) and implantation rates for those whose serum E2 increased were 31.1%, 27.0%, and 22.1% vs. 38.6%, 22.7%, and 38.6% (p=NS, chi-square) in those where serum E2 decreased. The study also confirms that using mild ovarian stimulation can result in reasonable live delivered pregnancy rates in women with diminished oocyte reserve as long as a mild dosage of follicle stimulating hormone (FSH) is used.