Effect of serum progesterone level on the day of human chorionic gonadotropin injection on outcome following in vitro fertilization-embryo transfer in women using gonadotropin releasing hormone antagonists.

摘要

PURPOSE: To determine if there is any association of serum progesterone (P) level at the time of human chorionic gonadotropin (hCG) injection and pregnancy outcome in in vitro fertilization (IVF) cycles using gonadotropin releasing hormone (GnRH) antagonists for controlled ovarian hyperstimulation (COH). METHODS: A retrospective analysis of IVF cycles over a six and a half-year period where either cetrorelix or ganirelix was used with COH and at least two embryos were transferred. Female partners were < or = 35. Four different serum progesterone (P) ranges were evaluated from < or = .5 ng/ml to 1.9 ng/ml; P was measured by ELISA. RESULTS: There was no significant difference in pregnancy rates or even a trend in that direction with increasing serum P levels with either GnRH antagonist. CONCLUSIONS: At least with COH cycles using GnRH antagonists and where serum P is measured by ELISA there does not seem to be any disadvantage of higher serum P levels up to 2 ng/ml at the time of hCG in IVF-ET cycles.