Anthocyanin-enriched Extracts from Aronia (Aronia melanocarpa E.) and Haskap (Lonicera caerulea L.) Suppressed KBrO3-induced Renal Damage in Rats

摘要

Aronia (Aronia melanocarpa E.) and haskap (Lonicera caerulea L.) fruits contain a number of bioactive phenolic phytochemicals, such as cyanidin 3-galactoside (aronia) and cyanidin 3-glucoside (haskap). We investigated the effects of anthocyanin-enriched aronia and haskap extracts (aronia extract and haskap extract) on potassium bromate (KBrO3)-induced renal and hepatic damage in rats. Treatment with aronia and haskap extracts (anthocyanin intake, 300 mg/kg B.W.) prior to KBrO3 administration (125 mg/kg B.W.) significantly inhibited kidney weight increases compared to the control (saline alone) rats. Blood urea nitrogen (BUN) and serum creatinine as well as aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities of rats administered the aronia extract were significantly lower than those of control rats, indicating that the aronia extract suppressed KBrO3-induced renal and hepatic damage. In addition, aronia and haskap extracts recovered decreases in oxygen radical absorbance capacity (ORAC) levels of serum and kidneys, and KBrO3 -induced increases in thiobarbituric acid reactive substance (TBARS) level of kidneys. These results suggest that aronia and haskap extracts ameliorated KBrO3-induced kidney and liver damage via enhancing antioxidant capacities in vivo.