Gastrointestinal stromal tumor (GIST), generally driven by oncogenic KIT or PDGFRA mutations, is the most common mesenchymal tumor of the gastrointestinal (GI) tract. GIST is most common in the stomach (60%) and small intestine (30%), but can occur anywhere in the GI-tract and the intra-abdominal soft tissues. GIST can show spindle cell or epithelioid morphology, and mitotic count and tumor size are most important prognostic parameters. GISTs in NF1 patients and children are distinctive clinicopathologic groups. Immunohistochemical testing for KIT and sometimes for DOG1/Ano 1 is essential in confirming the diagnosis.
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机译：胃肠道间质瘤（GIST）通常由致癌性KIT或PDGFRA突变驱动，是胃肠道（GI）最常见的间质肿瘤。 GIST在胃（60％）和小肠（30％）中最常见，但可以发生在胃肠道和腹内软组织的任何地方。 GIST可显示梭形细胞或上皮样形态，有丝分裂计数和肿瘤大小是最重要的预后参数。 NF1患者和儿童中的GIST是独特的临床病理学组。对KIT以及有时对DOG1 / Ano 1进行免疫组织化学测试对于确认诊断至关重要。
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