An efficient catalyst for the synthesis of ortho-substituted biaryls by the Suzuki cross-coupling: Triphenylphosphine adduct of cyclopalladated ferrocenylimine

摘要

The air and moisture stable triphenylphosphine adduct of cyclopalladated ferrocenylimine 2 has been successfully used in palladiumcatalyzed Suzuki cross-coupling for the synthesis of ortho-substituted biaryls in air. In the presence of 0.05 mol% of 2 as catalyst and 3 equivalent of CsF as base in dioxane at 100 degrees C, ortho-substituted biaryls were synthesized with moderate to high yields in the reactions of 2-methoxy-l-naphthylboronic acid with aryl halides, and 14 new ortho-substituted biaryls were obtained and characterized. (c) 2006 Elsevier B.V. All rights reserved.