Relationship between gestational fasting plasma glucose and neonatal birth weight, prenatal blood pressure and dystocia in pregnant Chinese women

摘要

Background: Little is known about the optimal cut-off point of fasting plasma glucose for the diagnosis of gestational diabetes mellitus for pregnant Chinese women. This study investigates the relationship between gestational fasting plasma glucose and several variables: neonatal birth weight, prenatal blood pressure and dystocia rate of pregnant women. In this study, we hoped to provide a useful tool to screen gestational diabetes mellitus in pregnant Chinese women. Methods: For 1058 pregnant women enrolled in our hospital at pregnancy weeks 22-30, fasting plasma glucose, neonatal birth weight and prenatal blood pressure, as well as dystocia conditions, were examined. We analysed the correlations between the following: gestational fasting plasma glucose and neonatal birth weight; prenatal blood pressure and gestational fasting plasma glucose as well as dystocia rate and gestational fasting plasma glucose group. Results: A modest correlation was observed between gestational fasting plasma glucose and neonatal birth weight (r=0.093, p=0.003). The macrosomia rate was smallest when the gestational fasting plasma glucose was in the range 3.51-5.5mmol/L. Prenatal blood pressure increased linearly with increasing gestational fasting plasma glucose (p=0.000). There was a significant difference between the dystocia rates in different fasting plasma glucose groups (chi-squared=13.015, p=0.043). The results showed that the dystocia rate significantly increased when gestational fasting plasma glucose was >4.9mmol/L; p=0.03, OR=2.156 (95% CI, 1.077-4.318). Conclusion: We suggest that the optimal range of gestational fasting plasma glucose for pregnant Chinese women is in the range 3.5-4.9mmol/L.