Insulin lispro low mixture twice daily versus basal insulin glargine once daily and prandial insulin lispro once daily in patients with type 2 diabetes requiring insulin intensification: a randomized phase IV trial

Tinahones F. J.; Gross J. L.; Onaca A.; Cleall S.; Rodriguez A.

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Insulin lispro low mixture twice daily versus basal insulin glargine once daily and prandial insulin lispro once daily in patients with type 2 diabetes requiring insulin intensification: a randomized phase IV trial

机译：需要胰岛素强化的2型糖尿病患者，每天两次使用lispro低剂量胰岛素与基础甘精胰岛素每日一次，餐前lispro胰岛素每日一次：一项随机IV期试验

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AimsTo compare the efficacy and safety of two insulin intensification strategies in patients with type 2 diabetes inadequately controlled on basal insulin glargine with metformin and/or pioglitazone.

机译：目的比较两种胰岛素强化策略在2型糖尿病患者中的作用，这些患者在用二甲双胍和/或吡格列酮对基础胰岛素甘精胰岛素控制不足的2型糖尿病患者中进行比较。

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《Diabetes, obesity & metabolism》 |2014年第10期|共8页
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Tinahones F. J.; Gross J. L.; Onaca A.; Cleall S.; Rodriguez A.;
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正文语种 eng
中图分类内分泌腺疾病及代谢病;
关键词
insulin glargine; insulin intensification; insulin lispro; insulin lispro mixture; type 2 diabetes;

机译：甘精胰岛素;胰岛素增强;赖脯胰岛素;赖脯胰岛素混合物;2型糖尿病;

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1. Insulin lispro low mixture twice daily versus basal insulin glargine once daily and prandial insulin lispro once daily in patients with type 2 diabetes requiring insulin intensification: a randomized phase IV trial [J] . Tinahones F. J., Gross J. L., Onaca A., Diabetes, obesity & metabolism . 2014,第10期

机译：需要胰岛素强化的2型糖尿病患者，每天两次使用lispro低剂量胰岛素与基础甘精胰岛素每日一次，餐前lispro胰岛素每日一次：一项随机IV期试验
2. Comparison of thrice-daily premixed insulin (insulin lispro premix) with basal-bolus (insulin glargine once-daily plus thrice-daily prandial insulin lispro) therapy in east Asian patients with type 2 diabetes insufficiently controlled with twice-daily premixed insulin: an open-label, randomised, controlled trial [J] . Jia Weiping, Xiao Xinhua, Ji Qiuhe, The lancet. Diabetes & endocrinology. . 2015,第4期

机译：东亚2型糖尿病患者每日两次三次预混胰岛素（赖脯胰岛素预混物）与基底推注（甘精胰岛素每天一次加三餐膳食赖脯胰岛素）的比较，每日两次预混胰岛素不能充分控制：标签，随机，对照试验
3. Comparison of insulin lispro protamine suspension versus insulin glargine once daily in basal-bolus therapies with insulin lispro in type 2 diabetes patients: a prospective randomized open-label trial. [J] . Koivisto V, Cleall S, Pontiroli AE, Diabetes, obesity & metabolism . 2011,第12期

机译：在2型糖尿病患者中使用赖脯胰岛素胰岛素进行基础推注治疗时，赖脯胰岛素鱼精蛋白悬浮液与甘精胰岛素每日一次的比较：一项前瞻性随机开放标签试验。
4. Prandial Oral Insulin (Generex Oral-lyn~(TM)) in Adult Type-1 DM Subjects Receiving Basal s.c. Twice Daily Isophane Insulin (NPH) [C] . Jaime Guevara-Aguirre, Marco Guevara-Aguirre, Jeannette Saavedra, Controlled Release Society Annual Meeting and Exposition . 2007

机译：成人基底节成年型1型DM受试者的餐后口服胰岛素（Generex Oral-lyn〜（TM））。每日两次异烟碱胰岛素（NPH）
5. A 4-month randomized controlled clinical trial of adjuvant Exenatide or Pramlintide versus insulin alone in pediatric type 1 diabetes mellitus: Effect on glycemic control. [D] . Withycombe, Sarah Elizabeth. 2010

机译：儿科1型糖尿病患者中艾塞那肽或普兰林肽与单独使用胰岛素的4个月随机对照临床试验：对血糖控制的影响。
6. Insulin lispro low mixture twice daily versus basal insulin glargine once daily and prandial insulin lispro once daily in patients with type 2 diabetes requiring insulin intensification: a randomized phase IV trial [O] . F J Tinahones, J L Gross, A Onaca, -1

机译：需加强胰岛素治疗的2型糖尿病患者每日两次lispro低剂量混合胰岛素与基础甘精胰岛素每日一次和餐前lispro胰岛素混合：一项随机的IV期试验
7. Insulin lispro low mixture twice daily versus basal insulin glargine once daily and prandial insulin lispro once daily in patients with type 2 diabetes requiring insulin intensification: a randomized phase IV trial [O] . F. J. Tinahones, J. L. Gross, A. Onaca, 2014

机译：胰岛素LISPRO低混合物两次每日两次，每日每日胰岛素胰岛素，患有胰岛素2型糖尿病患者每天一次，需要胰岛素强化：A随机期IV试验

Insulin lispro low mixture twice daily versus basal insulin glargine once daily and prandial insulin lispro once daily in patients with type 2 diabetes requiring insulin intensification: a randomized phase IV trial

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