Association analysis about HLA-DRB1, -DQB1 polymorphism and auto-antibodies against alpha(1)-adrenergic receptors in Chinese patients with essential hypertension.

摘要

The auto-antibodies against alpha(1)-adrenergic receptors (alpha(1)-AAs) with agonist activity likes norepinephrine have been discovered in patients with essential hypertension but the mechanism of alpha(1)-AA production remains unclear. We supposed the alpha(1)-AAs be correlated to the HLA-DQB1 and DRB1 alleles. Three hundred ninety-six patients with essential hypertension (EH) and 224 normotensives were enrolled, and DNA typing was detected by protein coupled receptor (PCR) amplification with sequence-specific primers. Analysis was performed by alpha(2) and logistic regression. There were the significant associations of the haplotype HLA-DQB1*0301-DRB1*04 with the prevalence of alpha(1)-AAs in hypertensive patients and it obviously added to the risk for the alpha(1)-AA production (adjusted P = 0.019, OR 4.037, 95% CI 1.259-12.947). In normotensives, the haplotype HLA-DQB1*05-DRB1*04 provided a strong predisposition in alpha (1)-AAs production (adjusted P = 0.024, OR 3.922, 95% CI 1.200-12.817). These results suggest the HLA-DRB1*04 might be the primary risk alleles associated with alpha(1)-AA production on the haplotypes HLA-DQB1*0301-DRB1*04 and HLA-DQB1*05-DRB1*04 and increased the risk for alpha (1)-AA production.