Factor V Leiden mutation and antiphospholipid syndrome: risk factors for atherosclerotic and arterial thromboembolic disease.

摘要

Thrombophilia has been associated with an increased risk of atherosclerosis and thromboembolic events. Although no definitive evidence exists linking thrombo-philic defects with arterial vascular disease, recent reports have suggested that as many as one quarter of new vascular referrals presenting with intermittent claudica-tion have evidence of thrombophilia as demonstrated by factor V Leiden mutation, antiphospholipid syndrome, lupus, or protein C and S deficiency (1). Screening selected populations in whom intermittent claudication cannot be accounted for, such as young patients and those without vascular risk factors, may uncover thrombophilic defects, thereby affecting patient management. Here we report a case in which a young man with no known vascular risk factors developed sudden-onset bilateral intermittent claudication as a result of significant arterial atherosclerotic and thromboembolic disease secondary to combined factor V Leiden mutation and antiphospholipid syndrome. Patient consent was obtained before the publication of this report. No institutional review board approval was required for this case report.