Factor V Leiden and other thrombotic risk factors in CHD and myocardial Infarction

摘要

Hemostatic imbalance might be an etiological factor in the transition of coronary-heart disease (CHD) to myocardial infarction (MI). Several polymorphisms in genes regulating coagulation and hemostasis have been described as risk factors for venous thrombosis. However, their contribution to the development of arterial thrombosis is still unresolved. There are many reports in literature dealing with the role of specific coagulation factors in MI, ischemic stroke or peripheral arterial occlusion (for references see [1]), but for none of them a clear association to CHD or MI was finally accepted.