Pharmacokinetics of firocoxib and its interaction with enrofloxacin in horses.

摘要

Firocoxib is a coxib-class nonsteroidal anti-in?ammatory drug (NSAID) approved for use in horses to control pain and in?ammation associated with osteoarthritis. It is a fast-acting cyclooxygenase (COX) inhibitor highly speci?c for the type 2 inducible form (Kvaternick et al., 2007). Inhibition of the COX-2 isozyme prevents the production of prostaglandins that function primarily as in?ammatory mediators; this inhibition leads to the therapeutic effects of NSAIDs (Fitzpatrick, 2004; Lees et al., 2004). The coxibs offer the bene?ts of nonselective NSAIDs, with fewer adverse side effects on renal function, gastric function, and coagulation making them safer for use in horses (Kvaternick et al., 2007).