Pharmacokinetics of diminazene diaceturate in healthy cats.

摘要

Survival of ?ve of six cats treated for acute cytauxzoonosis with diminazene aceturate has been reported (Greene et al., 1999). Diminazene, an aromatic diamidine, has been used to treat babesiosis and trypanosomiasis in dogs, leishmaniasis in humans, and a variety of other protozoal diseases in domestic livestock. It was administered at a dose of 2 mg ?kg IM (two doses, 1 week apart) in the few cats with C. felis infection. Diminazene was administered to seven cats experimentally infected with Trypanosoma evansi at a dose of 3.5 mg ?kg via intramuscular injection on ?ve consecutive days (DaSilva et al., 2009). The treatment was 85.7% ef?cacious in eliminating the parasite, and no adverse effects were observed. Although commercially available in both aceturate (MW 515.5) and diaceturate (MW 587.6) salts, the drug is not Food and Drug Administration approved for use in any species in the United States of America.