PREPARATION OF THE HYDROPHILIC DRUG DIMINAZENE DIACETURATE AS LIPID DRUG CONJUGATE (LDC) NANOPARTICLES

摘要

The hydrophilic, well water-soluble antitrypanosomal drug Diminazene-diaceturate was formulated as lipid drug conjugate (LDC) nanoparticles by using high pressure homogenization. DSC and IR were used to elaborate the structure and stoechiometry of the bulk material and the nanoparticles. LDC nanoparticles are a completion of the lipid based colloidal carrier systems with the ability of incorporating hydrophilic drugs in a high amount.