Oral bioavailability and pharmacokinetic profile of the amoxicillin-clavulanic acid combination after intravenous and oral gavage administration in broiler chickens

摘要

The amoxicillin–clavulanic acid combination is one of the most frequently used antibiotic combination in the human and in the veterinary practice alike. Wide therapeutic margin, bactericidal activity, broad antibacterial spectrum and adequate water solubility makes the combination theoretically appropriate for using it in the poultry industry. Although no MRL is established for clavulanic acid in chickens in the European Union, emerging resistance might necessitate the usage of clavulanate together with amoxicillin even in broiler chickens in the future.