Synthesis and characterization of s-triazine based 1,5-benzothiazepines and isoxazoles

摘要

Series of compounds 2,4-bis-phenylamino-6-[4'-{2"-(substituted phenyl/cinnamyl/2'"-furanyl/2'"-thienyl)-2",3"-dihydro-l",5"-benzothiazepine-4"-yl}phenyl amino]-s-triazine 7(a-f) were prepared by reaction of different chalcones and 2-amino thiophenol in the presence of glacial acetic acid. Chalcones 6(a-f) on cyclisation with hydroxylamine hydrochloride in the presence of alkali gave 2,4-bis-phenylamino-6-[4'-{5"-(substituted phenyl/cinnamyl/2'"-furanyl/2'"-thienyl)-2"-isoxazol-3"-yl}phenyl amino/-5-triazine 8(a-f). The products were characterized by elemental analysis, IR and ~1H NMR data. All the synthesized compounds have been evaluated for their in vitro antibacterial activity against four different strain viz. S. aureus (MTCC-96), B. subtilis (MTCC-441) (Gram-positive bacteria) and E. coli (MTCC-443), S. paratyphi-B (MTCC-733) (Gram-negative bacteria) by agar diffusion method.