Synthesis and antimicrobial activity of 2-(6-substituted-1,3-benzothiazol-2-yl)-N-(4-halophenyl)hydrazinecarbothioamide

摘要

A number of new 2-(6-substituted-1,3-benzothiazol-2-yl)-N-(4-halophenyI)hydrazinecarbothioamide(5a-o)have been synthesized and screened for antibacterial activity.Compounds having benzothiazole moiety possess diverse pharmacological activities viz.antibacterial,anticonvulsant,antitumour,antiinflammatory,antitubercular,etc.In this study a series of 2-(6-substituted-1,3-benzothiazol-2-yl)-N-(4-halophenyl)-hydrazinecarbothioamide(5a-o)have been prepared by refluxing equimolar quantity of 2-hydrazino-6-substituted-1,3-benzothiazole(3a-e)and 4-substituted phenyliso-thiocyanate(4a-c).