Synthesis and characterization of some 3-N-alkoxyphthalimido-5-arylidene-2-{[4-(4-substituted phenyl)-1,3-thiazol-2-yl]imino}-1,3-thiazolidin-4-ohes

摘要

4-Chloro/methyl phenacyl bromide 1a-b reacted with, thiourea to furnish 2-amino thiazole 2a-b through Hantzsch's process, which were converted to their th'iazoHdinone derivatives 4a-b, by the reaction of corresponding thiazolyl thiourea 3a-b with chloroacetic acid in the presence of sodium acetate. Subsequent treatment of 4a-b with aromatic aldehydes 5a-c, followed by condensation with ω-bromonlkoxyphthalimides 7a-b afforded titled compounds 8a-1