Decursin Production from Hairy Root Culture of Angelica gigas

摘要

Angelica gigas Nakai, commonly known as Korean Angelica, is a perennial herb belonging to the Umbelliferae family and one of the most important medicinal plants in Korea. For thousands of years, the roots of A. gigas has been used as traditional Oriental herbal medicine to treat anemia, abdominal pain, injuries, migraine, arthritis, and female afflictions, and the material has also been prescribed for health-promoting effects [Chi and Kim, 1970; Choi et al., 2003; Sarker andNahar, 2004]. Decursin (Fig. 1) and decursinol angelate (a decursin isomer), the major secondary metabolites of A. gigas, have significant neuroprotective, anticancer, and anti-androgen-receptor signaling activities [Kang et al., 2005; Yim et al., 2005; Quo et al., 2007].