SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF 2-AMINO -4-(2'-HYDROXYPHEN-1'-YL)-6-ARYL PYRIMIDINES

摘要

2-Amino pyrimidines are known for their physiological importance. With a view to get better therapeutic activity, some new-2-amino pyrimidines of type (II) were synthesised. 2'-Hydroxy chalcones (I) were condensed with guanidine nitrate in presence of aqueous sodium hydroxide (40%) in ethanol to give 2-amino-4-(2'-hydroxyphenyl)-6-aryl pyrimidine (II). Previously reported 2'-hydroxy chalcones have been prepared from-2'-hydroxy acetophenone with benzaldehyde.Recently reported other chalcones (I) were also prepared in the same way. The structures of the compounds have been supported by elemental analysis, IR and PMR spectral data.