Lower vitamin D is associated with white matter hyperintensity in elderly women with Alzheimer's disease and amnestic mild cognitive impairment

摘要

To the Editor: White matter hyperintensity (WMH) on brain magnetic resonance imaging (MRI) is prevalent in the aging brain and is associated with cognitive decline and mobility impairment.1'2 It is a clinical challenge to establish a prevention strategy for WMH. Although believed to be of vascular origin, the exact etiology of WMH remains unclear. Age and hypertension are consistent risk factors for WMH. High homocysteine levels, diabetes mellitus, hyperlipidemia, smoking, obesity, low vitamin B12 levels, and alcohol consumption are likely to increase WMH.