Low-dose methotrexate-induced skin toxicity: Keratinocyte dystrophy as a histologic marker

摘要

Background: Skin toxicity during low-dose methotrexate therapy is rare, ill described, and reported to have nonspecific histologic characteristics. Thus, misdiagnosis is common in patients with mucosal ulcers and/or skin erosions related to low-dose methotrexate.