Acquired bilateral nevus of Ota-like macules (Hori nevus): etiologic and therapeutic considerations.

摘要

BACKGROUND: Acquired bilateral nevus of Ota-like macules (ABNOM), also known as Hori nevus, is one of the most commonly acquired dermal facial melanocytoses among people with dark skin, especially Asian women. OBJECTIVE: The goals of this article were to review published work on ABNOM; address controversies about pathogenesis and therapeutic approach; and inspire further study. METHODS: Articles in the literature related to the description of ABNOM were extracted and summarized. RESULTS: Clinically, ABNOM occurs predominantly on the face of middle-aged women. Histologically, it is characterized by irregularly shaped, bipolar melanocytes dispersed through the mid to papillary dermis. Therapeutically, various pigment-targeting lasers have emerged as the major mode of treatment. LIMITATIONS: There is a notable absence of both biological insight into the cause of ABNOM and robust trials to effectively define a standardized therapy. The scattered reports in the literature preclude a more rigorous meta-analytical approach. CONCLUSION: Although there have been many reports on ABNOM since 1984, the pathogenesis still remains unclear and controversial, and treatment of ABNOM is still challenging.