Three-component reaction between triphenylphosphine, dialkyl acetylenedicarboxylate and 4-amino-5-alkyl-2,4-dihydro-1,2,4-triazole-3-thiones: an efficient one-pot synthesis of stable phosphorus ylides

摘要

Protonation of the reactive 1:1 intermediate produced in the reaction between dialkyl acetylenedicarboxy-lates and triphenylphosphine by 4-amino-5-alkyl-2,4-dihydro-1,2,4-triazole-3-thione leads to vinylphos-phonium salts which undergo Michael addition with the conjugate base of the NH-acid to produce highly functionalized, salt-free phosphorus ylides in excellent yields.