Myocardial Expression Levels of Micro-Ribonucleic Acids in Patients With Left Ventricular Assist DevicesSignature of Myocardial Recovery, Signature of Reverse Remodeling, or Signature With No Name?

摘要

Clinical studies have shown that medical and device therapies that reduce heart failure morbidity and mortality also lead to a decreased left ventricular (LV) volume and mass and restore a more normal elliptical shape to the ventricle. These changes are due to the changes in myocyte size, structure, and organization that, on a global level, are reflected in shifts of the LV end-diastolic pressure-volume relationship toward normal. For want of better terminology, these changes, which encompasses myriad changes at the molecular, cellular, tissue, and organ level, have been referred to as "reverse remodeling" (1,2).