Surface Properties of Amphiphilic Drugs in Presence of Cationic Surfactants

摘要

Surface properties of two amphiphilic drugs i.e. amitriptyline and imipramine have been studied in the absence and presence of some cationic surfactants i.e. alkyltriphenylphosphonium bromide [R = 16 (CTPB), R = 14 (TTPB)] and alkyldiethylcthanolammonium bromide [R = 16 (CDEEAB), R = 14 (TDEEAB)] by surface tension measurement at 300 K. The critical micelle concentration (CMC), maximum surface excess concentration at the air/water interface (F_(max)), minimum area per surfactant molecule at the air-water interface (A_(min)) and the surface pressure at the CMC (π_(cmc)) have been determined. F_(max) value increases and CMC/π_(cmc) decrease & with an increasing mole fraction of surfactants. The solubility of amphiphilic drugs in cationic surfactant systems has also been studied.