Helical tomotherapy-based craniospinal irradiation: mature outcomes of a prospective feasibility study

摘要

Objective The objective of the study was to report mature outcomes in patients treated on a prospective feasibility study of helical tomotherapy-based craniospinal irradiation. Methods Patients needing craniospinal irradiation were accrued, treated, and followed up longitudinally for survival and toxicity on an institutional review board-approved study. Results Twenty patients (median age of 15 years) constituted the study cohort. Tomotherapy-based craniospinal irradiation was well tolerated with self-limiting and reversible acute toxicity. Four (20 %) patients needed growth factor or platelet support during craniospinal irradiation. Significant late neuro-toxicity was seen in only one (5 %) patient.