Exploring the gene-environment nexus in eating disorders.

摘要

Early theories of eating disorders focused on aversive family and sociocultural factors as fundamental to the development of these problems. A progression of family, twin and molecular genetic studies has demonstrated a substantial role for genetic factors in the development of anorexia nervosa, bulimia nervosa and related traits. Paradoxically, genetic studies hold promise for refining and enriching our approach to understanding the impact of adverse environmental forces. The development of new and more sophisticated approaches for understanding the complex interplay of genetic and environmental effects will allow enhanced understanding of both risk and protective environmental factors and how they may influence expressions of underlying genetic vulnerabilities to eating disorders.