Chiral Separation of β_2-Blockers on Pirkle-Type Chiral Stationary Phases

摘要

Liquid chromatographic resolution of six racemic β_2-blockers including bambuterol, clenbuterol, clenpropol, fumoterol, mabuterol, and terbutaline was studied on two Pirkle-type chiral stationary phases (CSPs) such as α-Burke-2 and Pirkle-1J. By varying the mobile phase compositions, five of the six β_3-blocker.s were successfully resolved on α-Burke-2 CSP, while only two β_2-blockers were resolved on Pirkle-1J CSP.