Study of the Preparation Conditions of Silica Monoliths for HPLC

摘要

Preparation conditions of silica monoliths for high performance liquid chromatography (HPLC) were systematically studied. The monoliths eventually formed were examined in many aspects, including mechanical strength, skeleton size, through pore size, BET surface area, pore volume, etc. The mechanism of mesopore formation and parameters affecting mesopore structures, such as cythltrimethylamine bromide (CTAB) in the reaction mixture and after-treatment with ammonium hydroxide, were also studied in detail.