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首页> 外文期刊>Journal of psychopharmacology >Looking back (and in) to the future: A personal reflection on 'Serotonin autoreceptor function and antidepressant drug action' (Hjorth et al., 2000)
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Looking back (and in) to the future: A personal reflection on 'Serotonin autoreceptor function and antidepressant drug action' (Hjorth et al., 2000)

机译:回顾(和展望)未来:对“血清素自体受体功能和抗抑郁药作用”的个人反思(Hjorth等人,2000年)

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Our article in this journal some 15 years ago focussed on the role of serotonin (5-HT) autoreceptors in the mechanism of action of antidepressant drugs. Specifically in this regard, the results were summarised of rat microdialysis studies carried out to examine: (a) the relative importance of 5-HT1A and 5-HT1B autoreceptors, including (b) possible regional variation, and (c) potential changes in autoreceptor responsiveness following chronic selective serotonin reuptake inhibitor administration. In the present reflection piece, I recap some of the key findings against a brief background and provide an account of their bearing within the context of subsequent endeavours in the antidepressant drug research and development field. I conclude by shortly commenting on selected topics relevant to novel, interesting advances and avenues for future research.
机译:大约15年前,我们在该期刊上发表的文章集中于血清素(5-HT)自体受体在抗抑郁药作用机理中的作用。特别是在这方面,总结了大鼠微透析研究的结果,这些研究旨在检查:(a)5-HT1A和5-HT1B自体受体的相对重要性,包括(b)可能的区域差异,以及(c)自体受体的潜在变化慢性选择性5-羟色胺再摄取抑制剂给药后的反应性。在当前的反思文章中,我将简要概述一些关键发现,并在抗抑郁药研究和开发领域的后续工作中说明这些发现。最后,我简短地评论与新颖,有趣的进展和未来研究的途径相关的选定主题。

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