Influence of solvent on the ortho substituent effect in the alkaline hydrolysis of phenyl esters of substituted benzoic acids

摘要

The second-order rate constants k (dm~3mol~(-1) s ~(-1)) for the alkaline hydrolysis of phenyl esters of meta-, para-and ortho-substituted benzoic acids in aqueous 5.3 M NaClO_4 and 1.0 M Bu_4NBr were measured by UV/Vis spectrophotometry at 25 °C. The variations in the ortho inductive, ortho resonance, as well as meta and para polar effects with solvent parameters were studied using data for the alkaline hydrolysis of phenyl esters of substituted benzoic acids in various media. The dependence of the ortho substituent effect on solvent can be precisely described with the following equation: δlog k_(ortho) = log k _(ortho) - log k_H = 0.059 + 2.19σ_1 +0.304σ~°_R + 2.79E~B_s -0.016 δEσ_1-0.085δEσ~°_R, where δE is the solvent electrophilicity, δE = E_S-E _(H2O), characterizing the hydrogen-bond donating power of the solvent. The increase in the meta and para polar substituent effects with decrease in the solvent hydrogen-bond donor capacity (electrophilicity) was approximately to the same extent (-0.068δEσ~°_(m, p)) as the resonance term for the ortho substituents. The steric term of ortho substituents was independent of the solvent parameters. The variations in the ortho inductive, ortho resonance, as well as meta and para polar substituent effects with the solvent electrophilicity were to the same extent as in phenyl benzoates containing the substituents in the phenyl part. The substituent effects in the alkaline hydrolysis of ethyl benzoates appeared to vary with the solvent electrophilicity nearly to the same extent as in the alkaline hydrolysis of substituted phenyl esters of benzoic acids.