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首页> 外文期刊>Journal of nutrigenetics and nutrigenomics. >Association of Neuropeptide Y Gene rs16147 Polymorphism with Cardiovascular Risk Factors, Adipokines, and Metabolic Syndrome in Patients with Obesity
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Association of Neuropeptide Y Gene rs16147 Polymorphism with Cardiovascular Risk Factors, Adipokines, and Metabolic Syndrome in Patients with Obesity

机译：肥胖患者神经肽Y基因rs16147多态性与心血管危险因素，脂肪因子和代谢综合征的相关性

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Background and Aims: The NPY gene has 4 exons, and it is located at 7p15.1. The main genetic variant described in this gene is rs16147. The aim of this study was to investigate the relationship of NPY rs16147 with body weight, insulin resistance, serum adipokine levels, and risk of metabolic syndrome (MetS). Methods: A population of 1,005 obese patients was analyzed in a cross-sectional survey. Weight, fat mass, waist circumference, blood pressure, basal glucose, C-reactive protein, insulin, insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR]), lipid profile, and adipocytokine (leptin, adiponectin, and resistin) levels were measured. The genotype of the NPY gene polymorphism (rs16147) was studied. Results: Body mass index (1.0 +/- 0.1; p < 0.05), weight (2.8 +/- 0.4 kg; p < 0.05), fat mass (1.8 +/- 0.3 kg; p < 0.05), waist circumference (1.9 +/- 0.2 cm; p < 0.05), leptin level (15.4 +/- 8.2 ng/mL; p < 0.05), insulin level (5.1 +/- 1.3 mIU/L; p < 0.05), and HOMA-IR (1.4 +/- 0.1 units; p < 0.05) were lower in A allele carriers than in non-A allele carriers in males. Males with an A allele had a lower percentage of MetS (54.8 vs. 69.1%; p < 0.05), central obesity (94.5 vs. 100%; p < 0.05), and hyperglycemia (24.7 vs. 33.8%; p < 0.05) than non-A allele carriers. Logistic regression analysis indicated that male non-A allele carriers had an increased risk of MetS (odds ratio [OR] = 1.26, 95% confidence interval [CI] = 1.17-1.83; p = 0.034), an increased risk of central obesity (OR = 1.08, 95% CI = 1.02-1.11; p = 0.044), and an increased risk of hyperglycemia (OR = 1.20, 95% CI = 1.09-1.79; p = 0.028) after adjusting for age. Conclusions: In obese males, the rs164147 polymorphism of the NPY gene is associated with leptin, insulin level, HOMA-IR, and an increased risk of MetS and its related phenotypes, such as central obesity and hyperglycemia. (C) 2016 S. Karger AG, Basel
机译：背景与目的：NPY基因有4个外显子，位于7p15.1。该基因中描述的主要遗传变异是rs16147。这项研究的目的是调查NPY rs16147与体重，胰岛素抵抗，血清脂肪因子水平和代谢综合征（MetS）风险之间的关系。方法：在一项横断面调查中对1,005名肥胖患者进行了分析。体重，脂肪量，腰围，血压，基础葡萄糖，C反应蛋白，胰岛素，胰岛素抵抗（胰岛素抵抗的稳态模型评估[HOMA-IR]），脂质分布和脂肪细胞因子（瘦素，脂联素和抵抗素）测量水平。研究了NPY基因多态性（rs16147）的基因型。结果：体重指数（1.0 +/- 0.1; p <0.05），体重（2.8 +/- 0.4 kg; p <0.05），脂肪质量（1.8 +/- 0.3 kg; p <0.05），腰围（1.9 +/- 0.2 cm; p <0.05），瘦素水平（15.4 +/- 8.2 ng / mL; p <0.05），胰岛素水平（5.1 +/- 1.3 mIU / L; p <0.05）和HOMA-IR（在男性中，A等位基因携带者比非A等位基因携带者低1.4 +/- 0.1个单位; p <0.05）。具有A等位基因的男性具有较低的MetS百分比（54.8比69.1％; p <0.05），中枢肥胖（94.5比100％; p <0.05）和高血糖症（24.7 vs. 33.8％; p <0.05）比非A等位基因携带者。 Logistic回归分析表明，男性非A等位基因携带者发生MetS的风险增加（几率[OR] = 1.26，95％置信区间[CI] = 1.17-1.83; p = 0.034），中枢性肥胖的风险增加（调整年龄后，OR = 1.08，95％CI = 1.02-1.11; p = 0.044），高血糖风险增加（OR = 1.20，95％CI = 1.09-1.79; p = 0.028）。结论：在肥胖男性中，NPY基因的rs164147多态性与瘦素，胰岛素水平，HOMA-IR，MetS及其相关表型（如中心性肥胖和高血糖）的风险增加有关。 （C）2016 S.Karger AG，巴塞尔

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